Publications

SELECTED PUBLICATIONS

Click for the full publication list: Google Scholar

# equal contribution; * corresponding author 

J. Chen#, Y. Xu#, M. Zhou, S. Xu, A. J. Varley, A. Golubovic, R. Lu, K. C. Wang, M. Yeganeh, D. Vosoughic, B. Li*, Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects, Proc. Natl. Acad. Sci. U.S.A., 120 (50) e2309472120, 2023 [link] GEN News, EurekAlert, UofT News

B. Li#,*, I. Raji#, A. Gordon#, L. Sun, T. Raimondo, A. Jiang, R. Langer, D. Anderson*, Accelerating Ionizable Lipid Discovery for mRNA Delivery Using Machine Learning and Combinatorial Chemistry, Nature Materials, in press

B. Li#, A. Jiang#, I.Raji#, C. Atyeo, T. Raimondo, A. Gordon, L. Rhym, T. Samad, S. Bhatia, G. Alter, R. Langer, D. Anderson*, Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA, Nature Biomedical Engineering, 2023, doi.org/10.1038/s41551-023-01082-6 [link] MIT News, Science Daily, the Medical News, Endpoint News, Verve Times, MedicalXpress, Mirage News, My Science, ScienMag, Health Reporter

 Y. Xu#, S. Ma#,  H. Cui#, J. Chen, S. Xu, K. Wang, A. Varley, R. Lu, B. Wang*B. Li*, AGILE Platform: A Deep Learning-Powered Approach to Accelerate LNP Development for mRNA Delivery, bioRxiv, doi.org/10.1101/2023.06.01.543345. [link]

B. Li#, R. Manan#, S. Liang#, A. Gordon, A. Jiang, G. Gao, R. Langer, W. Xue*, D. Anderson*, Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing, Nature Biotechnology, 2023, doi.org/10.1038/s41587-023-01679-x [link]

Research briefing: B. Li, D. Anderson, Lipid nanoparticle-enabled gene editing in the lung via inhalation, Nature Biotechnology, 2023, doi.org/10.1038/s41587-023-01689-9 [link] Nature News & Views, MIT News, UofT News, Cystic Fibrosis News Today, The Medical News, The Science Times, Verve Times, Today Headline, AZO Life Sciences, EurekAlert!, SciTechDaily, Technology Networks, Tech Times, BioCentury, Medgadget, Signals, Front Line Genomics

 Y. Xu#, A. Golubovic#S. Xu#, A. PanB. Li*, Rational Design and Combinatorial Chemistry of Ionizable Lipids for RNA Delivery, Journal of Materials Chemistry B. 2023, doi.org/10.1039/D3TB00649B [link]

T. Young#, K. Wang#, A. Varley#, B. Li*, Clinical delivery of circular RNA: Lessons learned from RNA drug development, Advanced Drug Delivery Reviews, 2023, 197, 114826. [link]

A. Golubovic#, S. Tsai#, and B. Li*, Bioinspired Lipid Nanocarriers for RNA Delivery, ACS Bio Med Chem Au, 2023, https://doi.org/10.1021/acsbiomedchemau.2c00073. [link] Cover Story;  Highlighted as ACS Editor's Choice

Z. Yuan#, B. Li#, W. Gu, S. Luozhong, R. Li, S. Jiang*, Mitigating the Immunogenicity of AAV-Mediated Gene Therapy with an Immunosuppressive Phosphoserine-Containing Zwitterionic Peptide, J. Am. Chem. Soc. 2022, https://doi.org/10.1021/jacs.2c09484. [link

B. Li, Z. Yuan, P. Jain, Y. He, H. Hung, X. Lin, S. Jiang*, De novo design of functional zwitterionic biomimetic material for immunomodulation, Science Advances, 2020, 6, eaba0754. [link] Highlighted by Chemical & Engineering News

B. Li, Z. Yuan, Y. He, H. Hung, Y. He, P. Jain, S. Jiang*, Zwitterionic nanoconjugate enables safe and efficient lymphatic drug delivery, Nano Letters, 2020, 20, 6, 4693-4699. [link]

Z. Yuan#, B. Li#, L. Niu, Y. He, P. McMullen, S. Jiang*, Zwitterionic peptide cloak mimics protein surfaces for protein protection, Angewandte Chemie International Edition, 2020, 59, 1-5. [link]

J. Zheng, L. Fan, S. Qin, H. Li, M. Sang, R, Li, Y. Xu, H. Chen, Z. Yuan*, B. Li*, A bio-responsive near-infrared fluorescent probes for facile and persistent live-cell tracking, Small, 2020, 2002211. [link] Highlighted by Materials Views

B. Li, P. Jain, J. Ma, J. Smith, Z. Yuan, H. Hung, Y. He, X. Lin, K. Wu, S. Jiang*, Trimethylamine N-oxide derived zwitterionic polymers: a new class of ultralow fouling bioinspired materials, Science Advances, 2019, 5(6), eaaw9562. [link]

F. Wang, Z. Yuan, P. McMullen, R. Li, J. Zheng, M. Xu, Q. He, B. Li*, H. Chen*, Near-infrared-light-responsive lipid nanoparticles as an intelligent drug release system for cancer therapy, Chemistry of Materials, 2019, 31(11), 3948-56. [link]

B. Li, Z. Yuan, P. Zhang, A. Sinclair, P. Jain, K. Wu, T. Bai, S. Jiang*, Zwitterionic nanocages overcome the efficacy loss of biologic drugs, Advanced Materials, 2018, 30, 1705728. [link] Cover story; Highlighted by Materials Views, and the UW “2017-2018 year in review” News.

B. Li, Z. Yuan, P. McMullen, J. Xie, P. Jain, H. Hung, S. Xu, P. Zhang, X. Lin, K. Wu, S. Jiang*, A chromatin-mimetic nanomedicine for therapeutic tolerance induction, ACS Nano, 2018, 12(12), 12004-12014. [link] Highlighted by Science Translational Medicine.

B. Li, J. Xie, Z. Yuan, P. Jain, X. Lin, S. Jiang*, Mitigation of inflammatory immune responses with hydrophilic nanoparticles, Angewandte Chemie International Edition, 2018, 57, 4527-31. [link] Highlighted by the UW News

B. Li, Z. Yuan, H. Hung, J. Ma, P. Jain, C. Tsao, J. Xie, P. Zheng, X. Lin, S. Jiang*, Revealing the immunogenic risk of polymers, Angewandte Chemie International Edition, 2018, 57, 14069-72. [link]

B. Li, F. Wang, L. Gui, Q. He, Y. Yao, H. Chen*, The potential of biomimetic nanoparticles for tumor-targeted drug delivery, Nanomedicine, 2018, 13 (16), 2099-2118. [link]

D. Chen#, B. Li#, S. Cai, P. Wang, S. Peng, Y. Sheng, Y. Gu*, H. Chen*, Dual targeting luminescent gold nanoclusters for tumor imaging and deep tissue therapy, Biomaterials, 2016, 100, 1-16. [link]

H. Chen#, B. Li#, M. Zhang, K. Sun, Y. Wang, K. Peng, Y. Gu*, Characterization of tumor-targeting Ag2S quantum dots for cancer imaging and therapy in vivo, Nanoscale, 2014, 6(21), 12580-90. [link]

H. Chen#, B. Li#, C. Wang, X. Zhang, Z. Cheng, X. Dai, Y. Gu*, Characterization of a fluorescence probe based on gold nanoclusters for cell and animal imaging, Nanotechnology, 2012, 24(5), 055704. [link]