High Throughput Design of Biomaterials for RNA Delivery
RNA-based Vaccines and Immunomodulatory Therapy
Any protein antigen can be encoded and expressed by mRNA and circRNA, in principle enabling the development of personalized vaccines and immunomodulatory therapy fighting diseases as diverse as cancer, infections, and autoimmune diseases. The Li lab engineers LNPs to deliver and potentiate the action of antigens or therapeutics encoded by RNA. These LNPs offer special features of size and surface chemistry for penetration of interstitial and mucosal barriers to access lymphoid tissues and cellular targets efficiently, proactive immune stimulation/suppression, and appropriate subcellular release of sensitive RNA payload after endocytosis. The Li lab also investigates self-adjuvanted RNA that activates innate immune sensors to further enhance the efficacy of RNA-based vaccines or immunomodulatory therapy against cancer, infectious diseases, and autoimmunity.
Nonviral Delivery Techniques for Genome Editing Tools